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KMID : 1134820000290061083
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Journal of the Korean Society of Food Science and Nutrition
2000 Volume.29 No. 6 p.1083 ~ p.1089
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Effect of Different Levels of Ethanol Ingestion and Ethanol Withdrawal on Vitamins A and E Contents in Rats
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Seo Jung-Sook
Bae Min-Jung
Kim Jung-Mi
Bae Bok-Sun
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Abstract
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The present study was conducted to investigate the effect of different levels of ethanol ingestion and ethanol withdrawal on vitamins A and E contents in rats. Sprague-Dawley male rats were given a liquid diet containing 0, 10, 20 or 30% of their caloric intake as ethanol for 5 weeks. Ethanol withdrawal rats maintained first on 30% ethanol diet for 5 weeks and then on control diet for 2 weeks. Ethanol consumption had no effect on plasma retinol levels among treatment groups. However, in rats fed over 20% ethanol diet, hepatic level of retinol significantly decreased, especially, in 30% ethanol fed rats. Feeding the control diet after ethanol withdrawal did not restore the hepatic level of retinol decreased by ethanol consumption in rats. Hepatic level of retinyl palmitate decreased markedly in rats fed 30% ethanol diet compared to control rats. In the rats withdrawn ethanol, it decreased more significantly. Hepatic content of α-tocopherol decreased significantly in rats fed ethanol diet more than 10%. However it was recovered to some extent by ethanol withdrawal. The results suggest that chronic ingestion of ethanol decreased hepatic concentrations of vitamins A and E, especially, in rats fed ethanol diets more than 20%.
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KEYWORD
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ethanol, retinol, retinyl palmitate, ${\alpha}$-tocopherol
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